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Article

Astrocytoma (CNS WHO grade 4), IDH-mutant with co-occurrence of BRAF p.V600E mutation, and homozygous loss of CDKN2A.

Neuropathology : official journal of the Japanese Society of Neuropathology - 1 Oct 2023

Leske Henning, Blakstad Hanne, Lund-Iversen Marius, Skovholt Else Kathrine, Niehusmann Pitt, Ramm-Pettersen Jon-Terje, Skogen Karoline, Kongelf Geir, Sprauten Mette, Magelssen Henriette, Brandal Petter

Abstract excerpt

Molecular alterations nowadays play a crucial role in the diagnosis of brain tumors. Some of these alterations are associated with outcome and/or response to treatment, including sequence variants of isocitrate dehydrogenase (IDH) at position p.R132 or p.R172. Such IDH variants have so far been described in histone H3-wildtype primary brain tumors only in adult-type diffuse gliomas and are associated with a...

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Identifiers

PMID: 36754566
DOI: 10.1111/neup.12895

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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