Article
Non-canonical IDH1 and IDH2 mutations: a clonal and relevant event in an Italian cohort of gliomas classified according to the 2016 World Health Organization (WHO) criteria.
Journal of neuro-oncology - 1 Nov 2017
Visani Michela, Acquaviva Giorgia, Marucci Gianluca, Paccapelo Alexandro, Mura Antonella, Franceschi Enrico, Grifoni Daniela, Pession Annalisa, Tallini Giovanni, Brandes Alba A, de Biase Dario
Abstract excerpt
According to the 2016 World Health Organization (WHO) classification of tumors of the central nervous system, assessment of exon 4 mutations in isocitrate dehydrogenase 1 or 2 genes (IDH1 or IDH2) is an essential step in the characterization of gliomas. The p.R132H mutation is the most frequent alteration in IDH genes, however other non-canonical IDH mutations can be identified. The aim of this study is to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.