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Article

A computational strategy to improve the activity of tyrosine phenol-lyase for the synthesis of L-DOPA.

Scientific reports - 25 Oct 2024

Xu Jiayu, Ye Sheng, Guan Fenghui

Abstract excerpt

Enzymes with high catalytic activity and stability are essential for industrial production, yet most natural enzymes do not meet these requirements. Therefore, efficient strategies for enzyme engineering are crucial. In this study, we developed a cost-effective computational design strategy to enhance the activity of tyrosine phenol-lyase (TPL) for the production of L-DOPA. By integrating structural analysis with...

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Identifiers

PMID: 39455666
DOI: 10.1038/s41598-024-76111-8
PMCID: PMC11512013

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