Article
Distal design improves thermostability and enzyme activity of type III tyrosinase from Nitrosospira.
International journal of biological macromolecules - 1 Feb 2026
Han Mo, Li Mengli, Jia Ruoyu, Miao Ming, Zhang Tao
Abstract excerpt
Tyrosinase (TYR), a copper-containing oxidase pivotal in melanin synthesis, is widely distributed across animals, plants, and microorganisms. Despite its significant potential in biotechnology and industry, its practical application is hampered by limitations such as low catalytic efficiency and poor stability. To address these constraints, a highly active type III TYR from Nitrosospira (Sp2) was identified...
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