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Article

Regulate catalytic performance by engineering non-regular structure of extradiol dioxygenase: An entrance to bottom strategy.

International journal of biological macromolecules - 1 Nov 2024

Huang Zihao, Qin Deyuan, Abuduwupuer Xiemuxinuer, Cao Luxin, Piao Yingdan, Shao Zhengkang, Jiang Liyan, Guo Zheng, Gao Renjun

Abstract excerpt

Extradiol dioxygenase Tcu3516 is a home-sourced enzyme demonstrating potent aromatic phenol degradation capacity. To add to the advantageous modifications inside active cavity, this work reported a novel strategy to engineer rarely concerned non-regular structures around the entrance towards the active site at the bottom of cavity. Three structures, Loop region 1 (Loop1: Met173-Arg185), Loop region 2 (Loop2:...

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PMID: 39366601
DOI: 10.1016/j.ijbiomac.2024.136246

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