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Article

Identification and enhanced activity of the tyrosine phenol-lyase from Mycobacterium tuberculosis.

International journal of biological macromolecules - 1 Jan 2026

Liu Hengrui, Yang Xiaorong

Abstract excerpt

L-DOPA (3,4-dihydroxyphenyl-L-alanine) is a key drug for the Parkinson's disease. The global demand of L-DOPA is continuously increasing. Tyrosine phenol-lyase (TPL) is the environmentally friendly biocatalyst for L-DOPA biosynthesis. In this study, a novel TPL from Mycobacterium tuberculosis (Mt-TPL) was identified and expressed in Escherichia coli. The characterization of Mt-TPL indicated that the optimal...

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Identifiers

PMID: 41475646
DOI: 10.1016/j.ijbiomac.2025.149969

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