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Article

An efficient colorimetric high-throughput screening method for synthetic activity of tyrosine phenol-lyase.

Analytical biochemistry - 1 Nov 2018

Tang Xiao-Ling, Suo Hui, Zheng Ren-Chao, Zheng Yu-Guo

Abstract excerpt

Tyrosine phenol-lyase (TPL) naturally catalyzes the reversible β-elimination of l-tyrosine to phenol, pyruvate and ammonium. With its reverse reaction (synthetic activity), l-tyrosine and its derivatives could be synthesized with high atom economy, which are widely used in pharmaceutical industries. In this study, a high-throughput screening method for synthetic activity of TPL was developed. One of the...

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PMID: 30176231
DOI: 10.1016/j.ab.2018.08.026

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