Article

Combining Machine Learning and Directed Evolution for Optimization of a Monooxygenase

2026-08-03

Abstract excerpt

L-3,4-dihydroxyphenylalanine (L-Dopa) is an important pharmaceutical for the treatment of Parkinson’s disease and a precursor to numerous catechol-containing compounds. The flavin-dependent monooxygenase HpaBC is a promising biocatalyst for microbial L-Dopa production but exhibits limited native activity toward L-tyrosine. Although structure-based machine learning (ML) models have become increasingly popular for p...

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Literature Corpus work: 42a30572-ad45-5f65-9622-3559c938441a
DOI: 10.64898/2026.07.31.742090

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