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Article

Modifying recombinant purple acid phosphatase using computational design.

European biophysics journal : EBJ - 1 Jun 2026

Venkatramani Aishwarya, Ali Montader, Predeina Olga, Molloy Jennifer C, Sormanni Pietro, Hall Elizabeth A H

Abstract excerpt

Enhancing protein stability while maintaining activity is a long-standing challenge in protein engineering, as modifications that benefit one property often compromise another. In this study, we leveraged a computational design strategy, CamSol Combination, to make a first step to improve the stability of purple acid phosphatase (PAP), a metalloprotein known for its distinctive pink color. PAP serves as a...

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Identifiers

PMID: 40650743
DOI: 10.1007/s00249-025-01779-3
PMCID: PMC13319145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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