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Article

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.

The Journal of clinical investigation - 1 Mar 2013

Tchkonia Tamara, Zhu Yi, van Deursen Jan, Campisi Judith, Kirkland James L

Abstract excerpt

Aging is the largest risk factor for most chronic diseases, which account for the majority of morbidity and health care expenditures in developed nations. New findings suggest that aging is a modifiable risk factor, and it may be feasible to delay age-related diseases as a group by modulating fundamental aging mechanisms. One such mechanism is cellular senescence, which can cause chronic inflammation through the...

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Identifiers

PMID: 23454759
DOI: 10.1172/JCI64098
PMCID: PMC3582125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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