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Senescence: An Identity Crisis Originating from Deep Within the Nucleus.

Annual review of cell and developmental biology - 6 Oct 2022

Olan Ioana, Narita Masashi

Abstract excerpt

Cellular senescence is implicated in a wide range of physiological and pathological conditions throughout an organism's entire lifetime. In particular, it has become evident that senescence plays a causative role in aging and age-associated disorders. This is not due simply to the loss of function of senescent cells. Instead, the substantial alterations of the cellular activities of senescent cells, especially...

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PMID: 35804478
DOI: 10.1146/annurev-cellbio-120420-013537

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