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Article

Association study of common KLF1 variants with Hb F and Hb A2 levels in β-thalassaemia carriers of Portuguese ancestry.

Journal of genetics - 1 Jan 2024

Manco Licínio, Bento Celeste, Relvas Luís, Maia Tabita, Ribeiro Letícia

Abstract excerpt

Kruppel-like factor 1 (KLF1) is an essential erythroid-specific transcription factor. Several reports have shown that KLF1 gene mutations are associated with increased levels of Hb F and Hb A2. However, scarce population studies have analysed common KLF1 variations. This study examines the potential association with Hb F and Hb A2 levels in β-thalassemia (β-thal) carriers of Portugueseancestry of the four common...

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PMID: 39445566

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