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Article

Changes in HbA2 and HbF in alpha thalassemia carriers with KLF1 mutation.

Blood cells, molecules & diseases - 1 May 2017

Satta Stefania, Paglietti Maria Elisabetta, Sollaino Maria Carla, Barella Susanna, Moi Paolo, Desogus Maria Franca, Demartis Franca Rosa, Manunza Laura, Origa Raffaella

Abstract excerpt

α-thalassemia carriers are common in Mediterranean regions, particularly in the Sardinian population. Their haematological phenotype is characterized by reduced MCV and/or MCH with normal or slightly reduced HbA2 levels and normal HbF. Krüppel-like factor 1 (KLF1) is a pleiotropic erythroid transcription factor that is essential for haematopoiesis. Mutations in the KLF1 gene trigger a series of benign human red...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28342932
DOI: 10.1016/j.bcmd.2017.03.007

Genes

KLF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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