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Article

Does the Novel KLF1 Gene Mutation Lead to a Delay in Fetal Hemoglobin Switch?

Annals of human genetics - 1 May 2017

Hariharan Priya, Gorivale Manju, Colah Roshan, Ghosh Kanjaksha, Nadkarni Anita

Abstract excerpt

The Kruppel-like factor 1 (KLF1) gene is an essential transcription factor that is required for the proper maturation of the erythroid cells. Recent studies have reported that KLF1 variations are associated with increased fetal hemoglobin (HbF) levels. Here we report a novel KLF1 gene variation codon 211 A→G (c.632 A>G) in a family who was referred for hemoglobinopathy screening. Both parents were classical...

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Identifiers

PMID: 28369821
DOI: 10.1111/ahg.12191

Genes

KLF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Does the Novel KLF1 Gene Mutation Lead to a Delay in Fetal Hemoglobin Switch?PMID 28369821Read ↗

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