Article
Changes in hematological parameters in α-thalassemia individuals co-inherited with erythroid Krüppel-like factor mutations.
Clinical genetics - 1 Jul 2015
Yu L-H, Liu D, Cai R, Shang X, Zhang X-H, Ma X-X, Yan S-H, Fang P, Zheng C-G, Wei X-F, Liu Y-H, Zhou T-B, Xu X-M
Abstract excerpt
Phenotypic variations in α-thalassemia mainly depend on the defective α-globin gene number. Genetic modifiers of the phenotype of Hemoglobin H (HbH) disease were poorly reported, apart from β-thalassemia allele that was identified ameliorating the severity of α-thalassemia. Because erythroid Krüppel-like factor (KLF1) mutations can modulate the red blood phenotype, we evaluated its effect on the α-thalassemia...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.