Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KFL1 Gene Variants in α-Thalassemia Individuals with Increased Fetal Hemoglobin in a Chinese Population.

Hemoglobin - 1 May 2018

Jiang Fan, Qu Yan-Xia, Chen Gui-Lan, Li Jian, Zhou Jian-Ying, Zuo Lian-Dong, Liao Can, Li Dong-Zhi

Abstract excerpt

Krüppel-like factor 1 (KLF1) is a pleiotropic erythroid transcription factor that is a regulator of definitive erythropoiesis. The aim of this study was to detect KLF1 gene variants in α-thalassemia (α-thal) carriers with an increased Hb F level in a Chinese population, and determine the changes of hematological parameters as a result of interactions between KLF1 gene mutations and α-thal. Subjects with α-thal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Thalassemia
Share to Asian People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Erythrocyte Indices

Share to Fetal Hemoglobin

Share to Genetic Variation

Share to Hemoglobin A2

Share to Heterozygote

Share to Kruppel-Like Transcription Factors

Source

Identifiers

PMID: 30205725
DOI: 10.1080/03630269.2018.1486325

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KFL1 Gene Variants in α-Thalassemia Individuals with Increased Fetal Hemoglobin in a Chinese Population.PMID 30205725Read ↗

Changes in hematological parameters in α-thalassemia individuals co-inherited with erythroid Krüppel-like factor mutations.Semantic proximity Read ↗

KLF1 mutations are relatively more common in a thalassemia endemic region and ameliorate the severity of β-thalassemia.Semantic proximity Read ↗

KLF1 gene mutations in Chinese adults with increased fetal hemoglobin.Semantic proximity Read ↗

Identification and Functional Analysis of Known and New Mutations in the Transcription Factor KLF1 Linked with β-Thalassemia-like PhenotypesSemantic proximity Read ↗

A new Krüppel-like factor 1 mutation (c.947G > A or p.C316Y) in humans causes β-thalassemia minor.Semantic proximity Read ↗

Changes in HbA2 and HbF in alpha thalassemia carriers with KLF1 mutation.Semantic proximity Read ↗

Does the Novel KLF1 Gene Mutation Lead to a Delay in Fetal Hemoglobin Switch?Semantic proximity Read ↗

Compound Heterozygosity for KLF1 Mutations Causing Hemolytic Anemia in Children: A Case Report and Literature ReviewSemantic proximity Read ↗

Compound heterozygosity for KLF1 mutations is associated with microcytic hypochromic anemia and increased fetal hemoglobin.Semantic proximity Read ↗

Mutation Screening of the Krüppel-like Factor 1 Gene in Individuals With Increased Fetal Hemoglobin Referred for Hemoglobinopathy Investigation in South of Iran.Semantic proximity Read ↗

Krüppel-like factor 1: hematologic phenotypes associated with KLF1 gene mutations.Semantic proximity Read ↗

Genetic variation of Krüppel-like factor 1 (KLF1) and fetal hemoglobin (HbF) levels in β0-thalassemia/HbE disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.