Article
KLF1 mutations are relatively more common in a thalassemia endemic region and ameliorate the severity of β-thalassemia.
Blood - 31 Jul 2014
Liu Dun, Zhang Xinhua, Yu Lihua, Cai Ren, Ma Xiaoxia, Zheng Chengguang, Zhou Yuqiu, Liu Qiji, Wei Xiaofeng, Lin Li, Yan Tizhen, Huang Jiwei, Mohandas Narla, An Xiuli, Xu Xiangmin
Abstract excerpt
Mutations in human Krüppel-like factor 1 (KLF1) have recently been reported to be responsible for increased fetal hemoglobin (HbF) and hemoglobin A2 (HbA2). Because increased HbF and HbA2 levels are important features of β-thalassemia, we examined whether there is any relationship between KLF1 mutation and β-thalassemia in China. To do this, we first studied the incidence of KLF1 mutations in 2 Chinese...
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