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Article

Genetic variation of Krüppel-like factor 1 (KLF1) and fetal hemoglobin (HbF) levels in β0-thalassemia/HbE disease.

International journal of hematology - 1 Mar 2018

Khamphikham Pinyaphat, Sripichai Orapan, Munkongdee Thongperm, Fucharoen Suthat, Tongsima Sissades, Smith Duncan R

Abstract excerpt

Heterogeneity of HbF levels in β0-thalassemia/HbE disease has been reported to be associated with variations in clinical manifestations of the disease, and several genetic-modifying factors beyond the β-globin gene cluster have been identified as HbF regulators. Down-regulation or heterozygous mutations of Krüppel-like factor 1 (KLF1) is associated with elevated HbF levels in non-thalassemia subjects. This study...

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Source

Identifiers

PMID: 29067594
DOI: 10.1007/s12185-017-2357-3

Genes

KLF1

Variants

rs745347362

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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