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Article

Systemic inflammation and Alzheimer's disease.

Biochemical Society transactions - 1 Aug 2011

Holmes Clive, Butchart Joe

Abstract excerpt

A number of studies demonstrate disturbances of the central innate immune system in AD (Alzheimer's disease). In animal and human studies, there is evidence of close communication between systemic and central innate immune systems. Animal models of neurodegeneration show evidence of an exaggerated central innate immune response following systemic inflammation. Clinical studies of AD show evidence of increased...

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PMID: 21787320
DOI: 10.1042/BST0390898

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