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Molecular Pathogenesis and Treatment of Myelodysplastic Syndromes.

Internal medicine (Tokyo, Japan) - 1 Jan 2021

Nakajima Hideaki

Abstract excerpt

Myelodysplastic syndromes (MDS) are clonal hematological disorders arising from hematopoietic stem cells that have accumulated various genetic abnormalities. MDS are heterogeneous in nature but uniformly characterized by chronic and progressive cytopenia from ineffective hematopoiesis, dysplasia in single or multiple lineages, and transformation to acute leukemia in a subset of patients. The genomic landscape...

Topics

DNA Methylation
Humans
Leukemia, Myeloid, Acute
Mutation
Myelodysplastic Syndromes
RNA Splicing

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 32009100
DOI: 10.2169/internalmedicine.4214-19
PMCID: PMC7835461

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