Article
Molecular taxonomy of myelodysplastic syndromes and its clinical implications.
Blood - 10 Oct 2024
Bernard Elsa, Hasserjian Robert P, Greenberg Peter L, Arango Ossa Juan E, Creignou Maria, Tuechler Heinz, Gutierrez-Abril Jesus, Domenico Dylan, Medina-Martinez Juan S, Levine Max, Liosis Konstantinos, Farnoud Noushin, Sirenko Maria, Jädersten Martin, Germing Ulrich, Sanz Guillermo, van de Loosdrecht Arjan A, Nannya Yasuhito, Kosmider Olivier, Follo Matilde Y, Thol Felicitas, Zamora Lurdes, Pinheiro Ronald F, Pellagatti Andrea, Elias Harold K, Haase Detlef, Ganster Christina, Ades Lionel, Tobiasson Magnus, Palomo Laura, Della Porta Matteo Giovanni, Fenaux Pierre, Belickova Monika, Savona Michael R, Klimek Virginia M, Santos Fabio P S, Boultwood Jacqueline, Kotsianidis Ioannis, Santini Valeria, Solé Francesc, Platzbecker Uwe, Heuser Michael, Valent Peter, Finelli Carlo, Voso Maria Teresa, Shih Lee-Yung, Fontenay Michaela, Jansen Joop H, Cervera José, Gattermann Norbert, Ebert Benjamin L, Bejar Rafael, Malcovati Luca, Ogawa Seishi, Cazzola Mario, Hellström-Lindberg Eva, Papaemmanuil Elli
Abstract excerpt
ABSTRACT: Myelodysplastic syndromes (MDS) are clonal hematologic disorders characterized by morphologic abnormalities of myeloid cells and peripheral cytopenias. Although genetic abnormalities underlie the pathogenesis of these disorders and their heterogeneity, current classifications of MDS rely predominantly on morphology. We performed genomic profiling of 3233 patients with MDS or related disorders to...
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