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Article

Unraveling the molecular pathophysiology of myelodysplastic syndromes.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Feb 2011

Bejar Rafael, Levine Ross, Ebert Benjamin L

Abstract excerpt

Somatically acquired genetic abnormalities lead to the salient features that define myelodysplastic syndromes (MDS): clonal hematopoiesis, aberrant differentiation, peripheral cytopenias, and risk of progression to acute myeloid leukemia. Although specific karyotypic abnormalities have been linked to MDS for decades, more recent findings have demonstrated the importance of mutations within individual genes, focal...

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Identifiers

PMID: 21220588
DOI: 10.1200/JCO.2010.31.1175
PMCID: PMC3969457

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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