Article
The genetic and molecular pathogenesis of myelodysplastic syndromes.
European journal of haematology - 1 Sept 2018
Shallis Rory M, Ahmad Rami, Zeidan Amer M
Abstract excerpt
Myelodysplastic syndromes (MDS) comprise a diverse group of clonal and malignant myeloid disorders characterized by ineffective hematopoiesis, resultant peripheral cytopenias, and a meaningful increased risk of progression to acute myeloid leukemia. A wide array of recurring genetic mutations involved in RNA splicing, histone manipulation, DNA methylation, transcription factors, kinase signaling, DNA repair,...
Topics
- Biomarkers
- Chromosome Aberrations
- Clonal Evolution
- Drug Discovery
- Epigenesis, Genetic
- Gene Expression Regulation
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Molecular Targeted Therapy
- Mutation