Article
The genetic and molecular pathogenesis of myelodysplastic syndromes.
European journal of haematology - 1 Sept 2018
Shallis Rory M, Ahmad Rami, Zeidan Amer M
Abstract excerpt
Myelodysplastic syndromes (MDS) comprise a diverse group of clonal and malignant myeloid disorders characterized by ineffective hematopoiesis, resultant peripheral cytopenias, and a meaningful increased risk of progression to acute myeloid leukemia. A wide array of recurring genetic mutations involved in RNA splicing, histone manipulation, DNA methylation, transcription factors, kinase signaling, DNA repair,...
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