Article

Blebbistatin protects iPSC-CMs from hypercontraction and facilitates automated patch-clamp based electrophysiological study

2021-06-07

Abstract excerpt

Recently, there have been great advances in cardiovascular channelopathy modeling and drug safety pharmacology using human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). The automated patch-clamp (APC) technique overcomes the disadvantages of the manual patch-clamp (MPC) technique, which is labor intensive and gives low output. However, the application of the APC platform is still limited in iPSC...

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Literature Corpus work: e6bbfd8c-d699-54ba-bf7b-3a5d2ad648e6
DOI: 10.1101/2021.06.07.447362

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