Article

Simultaneous widefield voltage and interferometric dye-free optical mapping quantifies electromechanical waves in human iPSC-cardiomyocytes

2022-10-11

Abstract excerpt

<h4>ABSTRACT</h4> Coupled electro-mechanical waves define heart’s function in health and disease. Genetic abnormalities, drug-triggered or acquired pathologies can disrupt and uncouple these waves with potentially lethal consequences. Optical mapping of electrical waves using fluorescent dyes or genetically-encoded sensors in human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) offers mechanistic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cbf1f5b1-2fd8-51df-8122-c815cfd7bd9a
DOI: 10.1101/2022.10.10.511562

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Simultaneous widefield voltage and interferometric dye-free optical mapping quantifies electromechanical waves in human iPSC-cardiomyocytesDOI 10.1101/2022.10.10.511562Read

OptoDyCE-plate as an affordable high throughput imager for all optical cardiac electrophysiologySemantic proximity Read

Effective use of genetically-encoded optical biosensors for profiling signalling signatures in iPSC-CMs derived from idiopathic dilated cardiomyopathy patientsSemantic proximity Read

Robotic manipulation of cardiomyocytes to identify gap junction modifiers for arrhythmogenic cardiomyopathy.Semantic proximity Read

CRISPRi Gene Modulation and All-Optical Electrophysiology in Post-Differentiated Human iPSC-CardiomyocytesSemantic proximity Read

EFP Analyzer: A fast, accurate, and easy-to-teach program for analyzing Extracellular Field Potentials from iPSC-derived cardiomyocytesSemantic proximity Read

Dynamic Electrical Stimulation Promotes hiPSC-CM Differentiation and FunctionalitySemantic proximity Read

Bioelectrical signaling via domain wall migrationSemantic proximity Read

Syncytium cell growth increases IK1 contribution in human iPS-cardiomyocytesSemantic proximity Read

Volumetric imaging and computation to explore contractile function in zebrafish heartsSemantic proximity Read

Identifying drug response by combining measurements of the membrane potential, the cytosolic calcium concentration, and the extracellular potential in microphysiological systemsSemantic proximity Read

3D Spatiotemporal Activation Mapping of Cardiac Organoids Using Conformal Shell Microelectrode Arrays (MEAs)Semantic proximity Read

Field potential Imaging in human iPSC- derived Cardiomyocytes using UHD-CMOS-MEASemantic proximity Read