Article

INTEGRATION OF ENGINEERED “SPARK-CELL” SPHEROIDS FOR OPTICAL PACING OF CARDIAC TISSUE

2021-01-27

Abstract excerpt

Optogenetic methods for pacing of cardiac tissue can be realized by direct genetic modification of the cardiomyocytes to express light-sensitive actuators, such as channelrhodopsin-2, ChR2, or by introduction of light-sensitized non-myocytes that couple to the cardiac cells and yield responsiveness to optical pacing. In this study, we engineer three-dimensional “spark cells” spheroids, composed of ChR2-expressing...

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Literature Corpus work: 0d289f19-c8e4-5388-a450-7594fceb6829
DOI: 10.1101/2021.01.25.428177

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