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Article

I-Wire Heart-on-a-Chip I: Three-dimensional cardiac tissue constructs for physiology and pharmacology.

Acta biomaterialia - 15 Jan 2017

Sidorov Veniamin Y, Samson Philip C, Sidorova Tatiana N, Davidson Jeffrey M, Lim Chee C, Wikswo John P

Abstract excerpt

Engineered 3D cardiac tissue constructs (ECTCs) can replicate complex cardiac physiology under normal and pathological conditions. Currently, most measurements of ECTC contractility are either made isometrically, with fixed length and without control of the applied force, or auxotonically against a variable force, with the length changing during the contraction. The "I-Wire" platform addresses the unmet need to...

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Identifiers

PMID: 27818308
DOI: 10.1016/j.actbio.2016.11.009
PMCID: PMC5235983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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