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eQTL mapping in transgenic alpha-synuclein carrying Caenorhabditis elegans recombinant inbred lines.

Human molecular genetics - 6 Dec 2024

Huang Yuqing, Wang Yiru A, van Sluijs Lisa, Vogels Demi H J, Chen Yuzhi, Tegelbeckers Vivian I P, Schoonderwoerd Steven, Riksen Joost A G, Kammenga Jan E, Harvey Simon C, Sterken Mark G

Abstract excerpt

Protein aggregation of α-synuclein (αS) is a genetic and neuropathological hallmark of Parkinson's disease (PD). Studies in the model nematode Caenorhabditis elegans suggested that variation of αS aggregation depends on the genetic background. However, which genes and genetic modifiers underlie individual differences in αS pathology remains unknown. To study the genotypic-phenotypic relationship of αS...

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PMID: 39439404
DOI: 10.1093/hmg/ddae148
PMCID: PMC11630767

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