Article
Natural Genetic Variation Influences Protein Abundances in C. elegans Developmental Signalling Pathways.
PloS one - 1 Jan 2016
Singh Kapil Dev, Roschitzki Bernd, Snoek L Basten, Grossmann Jonas, Zheng Xue, Elvin Mark, Kamkina Polina, Schrimpf Sabine P, Poulin Gino B, Kammenga Jan E, Hengartner Michael O
Abstract excerpt
Complex traits, including common disease-related traits, are affected by many different genes that function in multiple pathways and networks. The apoptosis, MAPK, Notch, and Wnt signalling pathways play important roles in development and disease progression. At the moment we have a poor understanding of how allelic variation affects gene expression in these pathways at the level of translation. Here we report...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.