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Genetic insight into the relationship between inflammatory bowel disease and Clostridioides difficile infection.

mSphere - 21 Nov 2024

Cushing-Damm Kelly C, Chen Yanhua, Du Xiaomeng, Kuppa Annapurna, Raut Chinmay, Oliveri Antonino, Chen Vincent L, Vanderwerff Brett, Zawistowski Matt, Rao Krishna, Higgins Peter, Speliotes Elizabeth K

Abstract excerpt

Patients with inflammatory bowel disease (IBD) are at increased risk of Clostridioides difficile infection (CDI). Herein, we aimed to determine if genetic risk contributes to this observed association. We carried out a genome-wide association study (GWAS) analysis in the Michigan Genomics Initiative and the United Kingdom Biobank for CDI based on ICD codes and meta-analyzed these results with similar publicly...

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Identifiers

PMID: 39436105
DOI: 10.1128/msphere.00567-24
PMCID: PMC11580397

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