Article
Genetic risk factors for Clostridium difficile infection in ulcerative colitis.
Alimentary pharmacology & therapeutics - 1 Sept 2013
Ananthakrishnan A N, Oxford E C, Nguyen D D, Sauk J, Yajnik V, Xavier R J
Abstract excerpt
BACKGROUND: Patients with inflammatory bowel disease (IBD) are at higher risk for Clostridium difficile infection (CDI). Disruption of gut microbiome and interaction with the intestinal immune system are essential mechanisms for pathogenesis of both CDI and IBD. Whether genetic polymorphisms associated with susceptibility to IBD are also associated with risk of CDI is unknown. AIMS: To use a well-characterised...
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