Article
Genetic variation in the human leukocyte antigen region confers susceptibility to Clostridioides difficile infection.
Scientific reports - 28 Oct 2023
Ferar Kathleen, Hall Taryn O, Crawford Dana C, Rowley Robb, Satterfield Benjamin A, Li Rongling, Gragert Loren, Karlson Elizabeth W, de Andrade Mariza, Kullo Iftikhar J, McCarty Catherine A, Kho Abel, Hayes M Geoffrey, Ritchie Marylyn D, Crane Paul K, Mirel Daniel B, Carlson Christopher, Connolly John J, Hakonarson Hakon, Crenshaw Andrew T, Carrell David, Luo Yuan, Dikilitas Ozan, Denny Joshua C, Jarvik Gail P, Crosslin David R
Abstract excerpt
Clostridioides difficile (C. diff.) infection (CDI) is a leading cause of hospital acquired diarrhea in North America and Europe and a major cause of morbidity and mortality. Known risk factors do not fully explain CDI susceptibility, and genetic susceptibility is suggested by the fact that some patients with colons that are colonized with C. diff. do not develop any infection while others develop severe or...
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