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Article

Multinucleated giant cell phenotype in response to stimulation.

Immunobiology - 1 May 2020

Trout Kevin L, Holian Andrij

Abstract excerpt

Macrophages fuse into multinucleated giant cells (MGC) in many pathological conditions. Despite MGC correlations with granulomas, their functional contribution to inflammation is relatively unknown. An in vitro mouse model of IL-4-induced bone marrow-derived macrophage fusion and microfiltration were used to generate enriched MGC and macrophage populations. Phenotypes were compared in response to well-known...

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Identifiers

PMID: 32517879
DOI: 10.1016/j.imbio.2020.151952
PMCID: PMC7292728

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