Article
Regulation of extracellular matrix assembly and structure by hybrid M1/M2 macrophages.
Biomaterials - 1 Feb 2021
Witherel Claire E, Sao Kimheak, Brisson Becky K, Han Biao, Volk Susan W, Petrie Ryan J, Han Lin, Spiller Kara L
Abstract excerpt
Aberrant extracellular matrix (ECM) assembly surrounding implanted biomaterials is the hallmark of the foreign body response, in which implants become encapsulated in thick fibrous tissue that prevents their proper function. While macrophages are known regulators of fibroblast behavior, how their phenotype influences ECM assembly and the progression of the foreign body response is poorly understood. In this...
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