Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Catalytic activities of wild-type C. elegans DAF-2 kinase and dauer-associated mutants.

The FEBS journal - 1 Dec 2024

Krishnan Harini, Ahmed Sultan, Hubbard Stevan R, Miller W Todd

Abstract excerpt

DAF-2, the Caenorhabditis elegans insulin-like receptor homolog, regulates larval development, metabolism, stress response, and lifespan. The availability of numerous daf-2 mutant alleles has made it possible to elucidate the genetic mechanisms underlying these physiological processes. The DAF-2 pathway is significantly conserved with the human insulin/IGF-1 signaling pathway; it includes proteins homologous to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Phosphorylation

Share to Receptor, Insulin

Share to Signal Transduction

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 39428852
DOI: 10.1111/febs.17303
PMCID: PMC11705002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Catalytic activities of wild-type C. elegans DAF-2 kinase and dauer-associated mutants.PMID 39428852Read ↗

Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/IGF-1 receptor.Semantic proximity Read ↗

Caenorhabditis elegans DAF-2 as a Model for Human Insulin Receptoropathies.Semantic proximity Read ↗

An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans.Semantic proximity Read ↗

Quantitative mass spectrometry identifies insulin signaling targets in C. elegans.Semantic proximity Read ↗

pkc-1 regulates daf-2 insulin/IGF signalling-dependent control of dauer formation in Caenorhabditis elegans.Semantic proximity Read ↗

Partitioning of the truncated insulin receptor DAF-2B between homodimers and heterodimers influences insulin signaling in C. elegans.Semantic proximity Read ↗

Caenorhabditis elegans SDF-9 enhances insulin/insulin-like signaling through interaction with DAF-2.Semantic proximity Read ↗

Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family.Semantic proximity Read ↗

C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span.Semantic proximity Read ↗

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor.Semantic proximity Read ↗

DAF-16-dependent and independent expression targets of DAF-2 insulin receptor-like pathway in Caenorhabditis elegans include FKBPs.Semantic proximity Read ↗

The C. elegans DAF-2 insulin-like receptor is abundantly expressed in the nervous system and regulated by nutritional status.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.