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Article

Caenorhabditis elegans DAF-2 as a Model for Human Insulin Receptoropathies.

G3 (Bethesda, Md.) - 5 Jan 2017

Bulger David A, Fukushige Tetsunari, Yun Sijung, Semple Robert K, Hanover John A, Krause Michael W

Abstract excerpt

Human exome sequencing has dramatically increased the rate of identification of disease-associated polymorphisms. However, examining the functional consequences of those variants has created an analytic bottleneck. Insulin-like signaling in Caenorhabditis elegans has long provided a model to assess consequences of human insulin signaling mutations, but this has not been evaluated in the context of current genetic...

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Identifiers

PMID: 27856697
DOI: 10.1534/g3.116.037184
PMCID: PMC5217114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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