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Article

Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/IGF-1 receptor.

Genetics - 1 Feb 2008

Patel Dhaval S, Garza-Garcia Acely, Nanji Manoj, McElwee Joshua J, Ackerman Daniel, Driscoll Paul C, Gems David

Abstract excerpt

The DAF-2 insulin/IGF-1 receptor regulates development, metabolism, and aging in the nematode Caenorhabditis elegans. However, complex differences among daf-2 alleles complicate analysis of this gene. We have employed epistasis analysis, transcript profile analysis, mutant sequence analysis, and homology modeling of mutant receptors to understand this complexity. We define an allelic series of nonconditional...

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Identifiers

PMID: 18245374
DOI: 10.1534/genetics.107.070813
PMCID: PMC2248335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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