Article

Multidimensional atlas of RNA-regulated proteins revealed by RNA-dependent thermal proteome profiling

2026-07-16

Abstract excerpt

<h4>SUMMARY</h4> RNA and proteins interact pervasively in cellular processes, yet the functional relevance of most RNA-binding proteins remains unknown. To address this, we developed RNA-dependent thermal proteome profiling (RTPP), a method that identifies RNA-regulated proteins (RRPs) by detecting changes in a protein’s structural stability upon RNA binding, without requiring crosslinking or enrichment. Applying...

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Literature Corpus work: d07deb59-8481-5818-8b8e-ac8dc1eb5a70
DOI: 10.64898/2026.07.15.738841

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