Article

Integrative Structural Modeling of Intrinsically Disordered Regions in a Human HDAC2 Chromatin Remodeling Complex

2025-08-09

Abstract excerpt

Intrinsically disordered regions (IDRs) and intrinsically disordered proteins (IDPs) play pivotal roles in cellular signaling, molecular recognition, and the regulation of various biological processes. These flexible and conformationally dynamic protein segments are difficult to study using structural analysis methods and computational approaches including AlphaFold. Therefore a critical challenge arises when atte...

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Literature Corpus work: 0cff1cf3-56f8-5b3a-b1f6-497029ca9341
DOI: 10.1101/2025.08.08.669391

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