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Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm−oocyte fusion in mice

11 May 2020

Abstract excerpt

Significance The sperm−oocyte fusion step is important to transport the male genome into oocytes. So far, IZUMO1 and FIMP have been identified as fusion-related proteins in spermatozoa, but the molecular mechanisms underpinning sperm−oocyte fusion and all of the proteins required for this essential process remain unclear. In this study, using CRISPR-Cas9−mediated gene knockouts in mice, we discover that sperm...

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PMID: 32393636
DOI: 10.1073/pnas.1922650117

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