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Article

The Ly6/uPAR protein Bouncer is necessary and sufficient for species-specific fertilization.

Science (New York, N.Y.) - 7 Sept 2018

Herberg Sarah, Gert Krista R, Schleiffer Alexander, Pauli Andrea

Abstract excerpt

Fertilization is fundamental for sexual reproduction, yet its molecular mechanisms are poorly understood. We found that an oocyte-expressed Ly6/uPAR protein, which we call Bouncer, is a crucial fertilization factor in zebrafish. Membrane-bound Bouncer mediates sperm-egg binding and is thus essential for sperm entry into the egg. Remarkably, Bouncer not only is required for sperm-egg interaction but is also...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30190407
DOI: 10.1126/science.aat7113
PMCID: PMC6195191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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