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1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm–egg interaction

14 Feb 2023

Abstract excerpt

Sperm acrosomal membrane proteins, such as Izumo sperm–egg fusion 1 (IZUMO1) and sperm acrosome-associated 6 (SPACA6), play essential roles in mammalian gamete binding or fusion. How their biosynthesis is regulated during spermiogenesis has largely remained elusive. Here, we show that 1700029I15Rik knockout male mice are severely subfertile and their spermatozoa do not fuse with eggs. 1700029I15Rik is a type-II...

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PMID: 36787362
DOI: 10.1073/pnas.2207263120

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