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Article

Population variability in X-chromosome inactivation across 10 mammalian species.

Nature communications - 18 Oct 2024

Werner Jonathan M, Hover John, Gillis Jesse

Abstract excerpt

One of the two X-chromosomes in female mammals is epigenetically silenced in embryonic stem cells by X-chromosome inactivation. This creates a mosaic of cells expressing either the maternal or the paternal X allele. The X-chromosome inactivation ratio, the proportion of inactivated parental alleles, varies widely among individuals, representing the largest instance of epigenetic variability within mammalian...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39420003
DOI: 10.1038/s41467-024-53449-1
PMCID: PMC11487087

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