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Article

The critical role of Sirt1 in ischemic stroke

14 Mar 2025

Abstract excerpt

Ischemic stroke, the most prevalent form of stroke, is responsible for the highest disability rates globally and ranks as the primary cause of mortality worldwide. Sirt1, extensively investigated in neurodegenerative disorders, is the most well-known and earliest member of the sirtuins family. However, its mechanism of action during ischemic stroke remains ambiguous. The literature examination revealed the...

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PMID: 40160465
DOI: 10.3389/fphar.2025.1425560

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