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Article

Managing CDH1 Cancer Risks in a Child: Complex Decision Making in a Family With Hereditary Diffuse Gastric Cancer.

American journal of medical genetics. Part A - 1 Feb 2025

Agaoglu Nihat Bugra, Ng Ozden Hatirnaz, Zemheri Itir Ebru, Unal Busra, Gerenli Nelgin, Tosun Ilkay, Yazıcı Hulya, Ozbek Ugur, Kamihara Junne, Rana Huma Q

Abstract excerpt

Germline pathogenic variants (PVs) in CDH1 cause hereditary diffuse gastric cancer. The management of CDH1 cases with a positive family history includes total prophylactic gastrectomy or intensive surveillance. In this study, we report a 16-year-old boy with intramucosal gastric signet ring cells in the setting of a germline CDH1 PV and a family history of early-onset gastric cancer. The approach to managing both...

Topics

Humans
Stomach Neoplasms
Male
Cadherins
Antigens, CD
Adolescent
Genetic Predisposition to Disease
Germ-Line Mutation
Pedigree
Child
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gastrectomy

Decision Making

Source

Identifiers

PMID: 39392178
DOI: 10.1002/ajmg.a.63897

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-39392178-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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