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Article

Transcriptional repression by HDAC3 mediates T cell exclusion from Kras mutant lung tumors.

Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 2024

McGuire Caroline K, Meehan Ambryn S, Couser Evan, Bull Lois, Minor Allegra C, Kuhlmann-Hogan Alexandra, Kaech Susan M, Shaw Reuben J, Eichner Lillian J

Abstract excerpt

Histone Deacetylase 3 (HDAC3) function in vivo is nuanced and directed in a tissue-specific fashion. The importance of HDAC3 in Kras mutant lung tumors has recently been identified, but HDAC3 function in this context remains to be fully elucidated. Here, we identified HDAC3 as a lung tumor cell-intrinsic transcriptional regulator of the tumor immune microenvironment. In Kras mutant lung cancer cells, we found...

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Identifiers

PMID: 39388266
DOI: 10.1073/pnas.2317694121
PMCID: PMC11494357

Genes

HDAC3
KL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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