Article
Interplay between estrogen and Stat3/NF-κB-driven immunomodulation in lung cancer.
Carcinogenesis - 13 Nov 2020
Deng Shanshan, Ramos-Castaneda Marco, Velasco Walter V, Clowers Michael J, Gutierrez Berenice A, Noble Oscar, Dong Yiping, Zarghooni Melody, Alvarado Lucero, Caetano Mauricio S, Yang Shuanying, Ostrin Edwin J, Behrens Carmen, Wistuba Ignacio I, Stabile Laura P, Kadara Humam, Watowich Stephanie S, Moghaddam Seyed Javad
Abstract excerpt
K-ras mutant lung adenocarcinoma (LUAD) is the most common type of lung cancer, displays abysmal prognosis and is tightly linked to tumor-promoting inflammation, which is increasingly recognized as a target for therapeutic intervention. We have recently shown a gender-specific role for epithelial Stat3 signaling in the pathogenesis of K-ras mutant LUAD. The absence of epithelial Stat3 in male K-ras mutant mice...
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