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Article

Oncogenic epidermal growth factor receptor signal-induced histone deacetylation suppresses chemokine gene expression in human lung adenocarcinoma.

Scientific reports - 29 Mar 2023

Sumimoto Hidetoshi, Takano Atsushi, Igarashi Tomoyuki, Hanaoka Jun, Teramoto Koji, Daigo Yataro

Abstract excerpt

Epidermal growth factor receptor (EGFR)-mutated (mt) lung adenocarcinoma (LA) is refractory to immune checkpoint inhibitors (ICIs). However, the mechanisms have not been fully elucidated. CD8+ T cell infiltration was significantly lower in EGFR-mt than in EGFR-wild-type LA, which was associated with suppression of chemokine expression. Since this T cell-deserted tumor microenvironment may lead to the...

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Share to Adenocarcinoma of Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36991099
DOI: 10.1038/s41598-023-32177-4
PMCID: PMC10060241

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