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Article

Mutant KRAS Conversion of Conventional T Cells into Regulatory T Cells.

Cancer immunology research - 1 Apr 2016

Zdanov Stephanie, Mandapathil Magis, Abu Eid Rasha, Adamson-Fadeyi Saudat, Wilson Willie, Qian Jiahua, Carnie Andrea, Tarasova Nadya, Mkrtichyan Mikayel, Berzofsky Jay A, Whiteside Theresa L, Khleif Samir N

Abstract excerpt

Constitutive activation of the KRAS oncogene in human malignancies is associated with aggressive tumor growth and poor prognosis. Similar to other oncogenes, KRAS acts in a cell-intrinsic manner to affect tumor growth or survival. However, we describe here a different, cell-extrinsic mechanism through which mutant KRAS contributes to tumor development. Tumor cells carrying mutated KRAS induced highly suppressive...

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Source

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Identifiers

PMID: 26880715
DOI: 10.1158/2326-6066.CIR-15-0241
PMCID: PMC4884020

Genes

KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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