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Article

Hdac7 promotes lung tumorigenesis by inhibiting Stat3 activation

10 Nov 2017

Abstract excerpt

BACKGROUND: Lung cancer is the leading cause of cancer death worldwide. However, the molecular mechanisms underlying lung cancer development have not been fully understood. The functions of histone deacetylases (HDACs), a class of total eighteen proteins (HDAC1-11 and SIRT1-7 in mammals) that deacetylate histones and non-histone proteins, in cancers are largely unknown. METHODS: /K-Ras mice and HDAC7-depleted...

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PMID: 29126425
DOI: 10.1186/s12943-017-0736-2

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